Published in Health and Medicine Week, November 22nd, 2004
According to published research from the United States, "Chinese hamster ovary cells used for pharmaceutical protein production express noninfectious retrovirus-like particles. To assure the safety of pharmaceutical proteins, validation of the ability of manufacturing processes to clear retrovirus-like particles is required for product registration."
"Xenotropic murine leukemia virus (X-MuLV) is often used as a model virus for clearance studies. Traditionally," wrote L.M. Shi and coworkers, "cell-based infectivity assay has been the standard virus quantification method. In this...
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