Heart Failure
Corin gene is upregulated in hypertrophic cardiomyocytes and failing myocardium
Published in Health and Medicine Week, November 22nd, 2004
"High levels of plasma atrial natriuretic peptides (ANP) are associated with pathological conditions such as congestive heart failure (CHF). Recently, we have identified a cardiac serine protease, corin, that is the pro-ANP convertase. In [our] study, we examined the regulation of corin gene expression in cultured hypertrophic cardiomyocytes and in the left ventricular (LV) myocardium of a rat model of heart failure," investigators in the United States report.
K.L. Tran and colleagues of Berlex Biosciences explained,...
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