Human Herpesvirus 6
DC-SIGN expression altered at transcriptional level by HHV-6 infection
Published in Health and Medicine Week, November 22nd, 2004
"DC-SIGN expressed on dendritic cells (DCs) efficiently binds and transmits various pathogens, including human immunodeficiency virus, to lymphoid tissues and permissive cells. Consequently, alteration of DC-SIGN expression may affect susceptibility and resistance to pathogens.
"The present study shows that infection with human herpesvirus 6 (HHV-6) induces downregulation of DC-SIGN expression on immature DCs," scientists in Japan report.
"Expression levels of DC-SIGN mRNA and intracellular protein appeared to decrease following infection...
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