Kaposi Sarcoma Herpesvirus
KSHV ORF36 protein kinase activates c-Jun N-terminal kinase signaling pathway
Published in Health and Medicine Week, November 22nd, 2004
"Alpha-, beta-, and gamma-herpesviruses encode putative viral protein kinases. The herpes simplex virus UL13, varicella-zoster virus ORF47, and Epstein-Barr virus BGLF4 genes all show protein kinase domains in their protein sequences. Mutational analysis of these herpesviruses demonstrated that the viral kinase is important for optimal virus growth,"
"Previous studies have shown that ORF36 of Kaposi's sarcoma herpesvirus (KSHV) has protein kinase activity and is autophosphorylated on serine. The gene for ORF36 is expressed during lytic growth of the virus and has been...
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