Neuroimmunology
Effects of chronic IL-1 expression in brain characterized
Published in Health and Medicine Week, January 3rd, 2005
"Interleukin-1beta (IL-1) expression is associated with a spectrum of neuroinflammatory processes related to chronic neurodegenerative diseases," pathologists in Argentina explained. "The single-bolus microinjection of IL-1 into the central nervous system (CNS) parenchyma gives rise to delayed and localized neutrophil recruitment, transient blood-brain barrier (BBB) breakdown, but no overt damage to CNS integrity."
"However, acute microinjections of IL-1 do not mimic the chronic IL-1 expression, which is a feature of many CNS diseases," noted C.C. Ferrari and colleagues at...
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