Colorectal Cancer
NOD2 3020insC alone is not sufficient for colorectal cancer predisposition
Published in Health and Medicine Week, January 3rd, 2005
"Mutations in NOD2 have been shown to associate with increased susceptibility to Crohn's disease. A recent Polish study linked the truncating NOD2 3020insC variant with an increased risk of colorectal cancer (CRC) at an older age (>50 years) of disease onset, with an odds ratio of 2.23.
"We studied the possible contribution of the 3020insC variant to CRC risk in a series of 1,042 Finnish population-based patients from which 926 samples were successfully analyzed and in 348 anonymous cancer-free controls," scientists in Finland report.
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