Diabetes Pathogenesis
HLA transgenic mouse provides insights on autoimmune diabetes
Published in Health and Medicine Week, January 3rd, 2005
"Type 1 diabetes mellitus is a polygenic disease strongly associated with the class II molecules DR3, 4 and the linked DQ2, 8 alleles. These molecules play an important role in presentation of peptide antigens after intracellular processing to CD4 T lymphocytes. A number of in vitro approaches have been used to elucidate the molecular basis for the association of particular HLA alleles with susceptibility to or protection from type 1 diabetes mellitus. These have focused on the structure of the antigen-presenting molecules, together with their peptides," researchers in England and the United States...
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