Tobacco Use
Nicotine increases blood-brain barrier permeability in vivo
Published in Health and Medicine Week, January 24th, 2005
The BBB "is critical to the health of the central nervous system," researchers in the United States explained. "The BBB is formed primarily by the presence of tight junctions (TJ) between cerebral microvessel endothelial cells."
"In light of the known effects of nicotine on endothelial cell biology, the specific effects of nicotine on the in vivo BBB were examined," in a study conducted by B.T. Hawkins and coauthors at the University of Arizona. "Using in situ brain perfusion, it was found that continuous administration of nicotine (4.5 mg free base/kg/day) for 1 and 7 days led to...
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