Oncology
Uncleavable pro-scatter factor obstructs tumor growth and dissemination
Published in Health and Medicine Week, January 31st, 2005
"Scatter factor (SF), also known as hepatocyte growth factor, is ubiquitously present in the extracellular matrix of tissues in the form of an inactive precursor (pro-SF). In order to acquire biological activity pro-SF must be cleaved by specific proteases present on the cell surface. The mature form of SF controls invasive cues in both physiological and pathological processes through activation of its receptor, the Met tyrosine kinase," investigators in Italy report.
"By substituting a single amino acid in the proteolytic site, we engineered an unprocessable form of pro-SF...
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