Drug Development
Hybrid viral vectors generate site-specific gene incorporation
Published in Health and Medicine Week, January 31st, 2005
"Uncontrolled insertion of gene transfer vectors into the human genome is raising significant safety concerns for their clinical use. The wild-type adeno-associated virus (AAV) can insert its genome at a specific site in human chromosome 19 (AAVS1) through the activity of a specific replicase/integrase protein (Rep) binding both the AAVS1 and the viral inverted terminal repeats (ITRs). AAV-derived vectors, however, do not carry the rep gene and cannot maintain site-specific integration properties," investigators in Italy report.
"We describe a novel hybrid vector carrying an integration...
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