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Adenovirus
Adenovirus protein 100k examined, translational regulation elucidated
June 13th, 2005
Recent research from the United States has elucidated the regulation of translation by ribosome shunting through phosphotyrosine-dependent coupling of adenovirus protein 100k to viral mRNAs. "Adenovirus simultaneously inhibits cap-dependent host cell mRNA translation while promoting the translation of its late viral mRNAs during infection. Studies previously demonstrated that tyrosine kinase activity plays a central role in the control of late adenovirus protein synthesis," wrote Q.R. Xi and colleagues, New York University. "The tyrosine kinase inhibitor genistein decreases late viral mRNA translation and prevents viral inhibition of cellular protein...
Source: Health & Medicine Week (2005-06-13)
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