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Apoptosis
Researchers' work adds to apoptosis body of knowledge
June 13th, 2005
Apoptosis data are the focus of recent research from Japan, Sweden and the United States. Study 1: According to recent research published from Japan, p53 binding protein 2 (53BP2) induces apoptosis through the mitochondrial death pathway. "53BP2 has been identified as the interacting protein to p53, Bcl-2, and p65 subunit of nuclear factor kappaB (NF-kappaB). The TP53BP2 gene encodes two splicing variants, 53BP2S and 53BP2L, previously known as apoptosis stimulating protein 2 of p53 (ASPP2). We found that these 53BP2 proteins are located predominantly in the cytoplasm and induce apoptosis as demonstrated by cleavage of poly ADP ribose polymerase...
Source: Health & Medicine Week (2005-06-13)
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