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Alzheimer Disease
Amyloid beta-mediated oxidation studied, proteomic identification reported
June 13th, 2005
A study from the United States has elucidated the proteomic identification of proteins specifically oxidized by intracerebral injection of amyloid beta-peptide into rat brain. "Protein oxidation has been shown to result in loss of protein function. There is increasing evidence that protein oxidation plays a role in the pathogenesis of Alzheimer disease (AD)." "Amyloid beta-peptide (1-42) [Abeta(1-42)] has been implicated as a mediator of oxidative stress in AD. Additionally, Abeta(1-42) has been shown to induce cholinergic dysfunction when injected into rat brain, a finding consistent with cholinergic deficits documented in AD," wrote D. Boyd-Kimball...
Source: Health & Medicine Week (2005-06-13)
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