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Antimicrobial Resistance
Ciprofloxacin-resistant Pseudomonas aeruginosa investigated
June 13th, 2005
Researchers investigate alterations in the GyrA and GyrB Subunits of topoisomerase II and the ParC and ParE subunits of topoisomerase IV in ciprofloxacin-resistant clinical isolates of Pseudomonas aeruginosa in a recent issue of the International Journal of Antimicrobial Agents. "The presence of fluoroquinolone resistance-associated alterations in topoisomerase II and IV were investigated for 103 nfxC-like type Pseudomonas aeruginosa isolates. The most nfxC-like type isolates (98.1%) possessed the substitution of Ile for Thr-83 in GyrA. A single alteration in GyrA (Thr-83 -> Ile) was the most frequently detected and the next common alteration was...
Source: Health & Medicine Week (2005-06-13)
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