Multiple Sclerosis
Interferon-beta-1a induces increases in vascular cell adhesion molecule
Published in Health and Medicine Week, June 20th, 2005
According to a study from the United States, "We investigated soluble vascular cell adhesion molecule-1 (sVCAM) levels and MRI lesions over 24 weeks in 15 Relapsing Remitting MS (RRMS) patients randomized prospectively to receive once-weekly (qw) IFN-beta-1a 30 mu g intramuscularly (IM) (Group 1, 8 patients) or 3-times-weekly (tiw) IFN-beta-1a 44 mcg subcutaneously (SC) (Group II, 7 patients).
"Both groups demonstrated a significant increase in sVCAM during treatment when compared to pretreatment levels. Patients on IFN-beta-1a 44 mu g SC tiw had a significant (p<0.0001)...
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