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Rheumatoid Arthritis

Clinical trial results generalizable to routine practice

Published in Health and Medicine Week, June 20th, 2005

The results of clinical trials involving rheumatoid arthritis patients are generalizable to routine practice.

"Trials of disease-modifying anti-rheumatic drugs (DMARDs) enroll active rheumatoid arthritis patients identified using standard criteria (three out of four of: {{>=}}6 tender joints, {{>=}}6 swollen joints, ESR {{>=}}28 mm/h, {{>=}}45 min morning stiffness)," rheumatologists in England explained.

"Concern has been expressed about generalizability, as many patients in routine practice have less active disease," noted G.H. Kingsley and colleagues at the University of London. "Furthermore, these criteria do not map onto standard...

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