Phosphatase
New data illuminates research in phosphatase
Published in Health and Medicine Week, July 11th, 2005
Study 1: According to recent research published in the Journal of Biological Chemistry, expression of CD45 lacking the catalytic protein tyrosine phosphatase domain modulates Lck phosphorylation and T cell activation.
"The function of the second protein tyrosine phosphatase domain (D2) in two-domain protein tyrosine phosphatases (PTP) is not well understood. In CD45, D2 can interact with the catalytic domain (D1) and stabilize its activity," wrote Y.N. Wang and colleagues, University of British Columbia.
"Although D2 itself has no detectable catalytic activity, it can...
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