Acetylcholine Receptors
Thalamocortical synapses studied, hypocretin and nicotine responses defined
Published in Health and Medicine Week, July 11th, 2005
"Thalamic projections to prefrontal cortex are important for executive aspects of attention. Using two-photon imaging in prefrontal brain slices, we show that nicotine and the wakefulness neuropeptide hypocretin (orexin) excite the same identified synapses of the thalamocortical arousal pathway within the prefrontal cortex," wrote E.K. Lambe and colleagues, Connecticut Mental Health Center.
"Although it is known that attention can be improved when nicotine is infused directly into the midlayer of the prefrontal...
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