Hepatitis C Virus
Data advance knowledge in hepatitis c virus research
Published in Health and Medicine Week, July 11th, 2005
Study 1: Researchers at the U.S. Food and Drug Administration have proposed a new antiviral pathway that mediates hepatitis C virus (HCV) replicon interferon sensitivity through ADAR1 (double-stranded RNA).
"While many clinical hepatitis C virus (HCV) infections are resistant to alpha interferon (IFN-alpha) therapy, subgenomic in vitro self-replicating HCV RNAs (HCV replicons) are characterized by marked IFN-alpha sensitivity. IFN-alpha treatment of replicon-containing cells results in a rapid loss of viral RNA via translation inhibition through...
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