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Cosmetics

OTC progesterone cream results in significant drug exposure

Published in Health and Medicine Week, July 18th, 2005

Over-the-counter (OTC) progesterone cream produces significant drug exposure compared to a Food and Drug Administration-approved oral progesterone product.

According to recent research from the United States, "Progesterone products are available in prescription form as well as over-the-counter (OTC) topical preparations sold for 'cosmetic' uses.

"In a randomized study design, the authors compared the drug exposure from an OTC progesterone cream to a Food and Drug Administration-approved oral preparation at the labeled daily doses recommended for each product. Twelve healthy postmenopausal women received 200 mg oral progesterone capsules once daily...

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