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Allergy Medicine
Mast cell degranulation and allergies studied, role of T cell kinase revealed
July 25th, 2005
According to recently published research from Sweden, interleukin-2-inducible T cell kinase regulates mast cell degranulation and acute allergic responses. "Bruton's tyrosine kinase (Btk) is thought to positively regulate mast cell activation, implying a role in allergic responses. We have compared acute and late phase allergic airway reactions in mice lacking either Btk or interleukin-2-inducible T cell kinase (Itk), another Tec kinase expressed in mast cells," wrote J. Forssell and colleagues, University of Lund Hospital. "Btk(-/-) mice showed minor protection against allergic symptoms when challenged with allergen via the airways. In sharp...
Source: Health & Medicine Week (2005-07-25)
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