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Allergy Medicine
Molecule resembling grass pollen epitopes developed for allergy vaccine
July 25th, 2005
Scientists have developed a hybrid molecule resembling the epitope spectrum of grass pollen for allergy vaccination. "Allergy vaccines based on natural allergen extracts contain greatly varying amounts of individual allergens with different immunogenicity. The objective was to develop a novel type of allergy vaccine for complex allergen sources that combines defined amounts of the major allergens in the form of single hybrid molecules. A hybrid molecule was engineered by PCR-based mending and expression of the cDNAs coding for the four major grass pollen allergens and compared with its single components by circular dichroism analysis, T-cell proliferation, ELISA...
Source: Health & Medicine Week (2005-07-25)
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