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Alzheimer Disease
Alzheimer disease examined, iron oxidization of rRNA described
July 25th, 2005
According to a recent study from the United States, ribosomal RNA (rRNA) in Alzheimer disease is oxidized by bound redox-active iron. "Oxidative modification of cytoplasmic RNA in vulnerable neurons is an important, well documented feature of the pathophysiology of Alzheimer disease. Here we report that RNA-bound iron plays a pivotal role for RNA oxidation in vulnerable neurons in Alzheimer disease brain," wrote K. Honda and colleagues, Case Western Reserve University. "The cytoplasm of hippocampal neurons showed significantly higher redox activity and iron(II) staining than age-matched controls. Notably, both were susceptible to RNase, suggesting a...
Source: Health & Medicine Week (2005-07-25)
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