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Alzheimer Disease
Alzheimer disease hippocampus studied, fas-associated phosphatase localized
July 25th, 2005
A recent study from Switzerland has reported on the immunohistochemical localization of fas-associated phosphatase-1 (FAP-1) in Alzheimer disease hippocampus. "FAP-1 is a regulatory peptide inhibiting apoptotic signal transduction via the death receptor Fas. Because apoptosis is a common mechanism leading to neuronal death in neurodegenerative disorders, the authors investigated the immunohistochemical distribution of FAP-1 in the hippocampus of elderly control subjects and Alzheimer disease (AD) patients," wrote E. Savaskan and colleagues, University of Basel. "The current study provides the first evidence that FAP-1 is localized in the human...
Source: Health & Medicine Week (2005-07-25)
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