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Amyotrophic Lateral Sclerosis
Researchers provide details of new studies and findings in the area of amyotrophic lateral sclerosis
July 25th, 2005
New findings from the United Kingdom and United States describe advances in amyotrophic lateral sclerosis. Study 1: Recent research from England has documented the structural consequences of a familial amyotrophic lateral sclerosis (FALS) mutant. "The His-46-Arg (H46R) mutant of human copper-zinc superoxide dismutase (SOD1) is associated with an unusual, slowly progressing form of FALS. Here we describe in detail the crystal structures of pathogenic H46R SOD1 in the Zn-loaded (Zn-H46R) and metal-free (apo-H46R) forms," wrote S. Antonyuk and colleagues, SERC. "The Zn-H46R structure demonstrates a novel zinc coordination that...
Source: Health & Medicine Week (2005-07-25)
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