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Angiotensin
Angiotensin type analyzed, receptor antagonist activity documented
July 25th, 2005
According to recently published research from the United States, sarcosine-1, glycine-8 angiotensin II (SG Ang II) is a functional AT1 angiotensin receptor antagonist. "SG Ang II displayed unusual characteristics in early pharmacological studies. It was a potent antagonist of the dipsogenic actions of intracerebroventricularly administered Ang II in the rat, but showed low affinity for bovine cerebellar Ang II receptors," wrote R.C. Speth and colleagues, University of Mississippi. "It has recently been shown that SG Ang II binds preferentially to the AT1 receptor. To determine if SG Ang II is a functional antagonist of the AT, receptor-mediated...
Source: Health & Medicine Week (2005-07-25)
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