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Antigen Presentation
Cytoplasmic antigen presentation examined, role of lysosome protein revealed
July 25th, 2005
According to recent research from the United States published in the journal Immunity, lysosome-associated membrane protein-2 (Lamp-2) facilitates MHC class II presentation of cytoplasmic antigens. "Extracellular antigens are internalized and processed before binding MHC class II molecules within endosomal and lysosomal compartments of professional antigen presenting cells (APC) for subsequent presentation to T cells. Yet select cytoplasmic peptides derived from autoantigens also intersect and bind class II molecules via an unknown mechanism," wrote D.L. Zhou and colleagues, Indiana University. "In human B lymphoblasts, inhibition of the...
Source: Health & Medicine Week (2005-07-25)
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