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Antipsychotic Therapy
Astrocytes mediate suppressive effects of clozapine on GLT-1 activity
July 25th, 2005
Astrocytes play a key role in the antipsychotic effects of clozapine. In a recent study, neuroscientists in Spain sought to "test the hypothesis that clozapine-induced reduction of glutamate transporter-1 (GLT-1) expression is mediated by astrocytes." A. Vallejo-Illarramendi and coauthors at the Universidad del País Vasco in Leioa evaluated the "effects of clozapine on Glu transporters and Glu uptake in primary astrocyte cultures of the cerebral cortex." "Astrocyte cultures treated for 48 h with clozapine exhibited a reduction in GLT-1 levels of about 50%, whereas glutamate-aspartate transporter (GLAST) levels remained unchanged,"...
Source: Health & Medicine Week (2005-07-25)
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