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Genomics

Researchers identify gene's role in suppressing longevity

Published in Health and Medicine Week, August 15th, 2005

Researchers have determined that a gene present in mouse cells limits the number of times that a cell can divide.

The gene is involved in a process, called senescence, which is thought to ensure that aging cells do not pass on harmful mutations.

The researchers said the gene, known as SIRT1, suppresses longevity, and may play a role in regulating the aging process. But they caution against interpreting the results too broadly, because dividing mouse cells in culture are an imperfect model of how aging affects human cells.

"That was quite surprising, because the findings in yeast and other lower organisms led those in field to...

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