Acetylcholine Receptors

Thymic toll-like receptor studied, increase in myasthenic patients shown

Published in Health and Medicine Week, August 15th, 2005

Recently published research from Italy has reported an increased toll-like receptor (TLR) 4 expression in the thymus of myasthenic patients with thymitis and thymic involution.

"Thymic abnormalities are present in approximately 80% of myasthenia gravis (MG) patients, and the thymus seems to be the main site of autosensitization to the acetylcholine receptor.

"In view of findings that the innate immune system can generate an autoimmune response, we studied the expression of TLRs 2 to 5, key components of innate immunity signaling pathways, in 37 thymuses from patients with autoimmune MG," wrote P. Bernasconi and colleagues, National Institute of...

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Source: Health and Medicine Week (2005-08-15)

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