Acute Coronary Syndrome
CX3CR1 I249 not balanced by M280 confers elevated risk of ACS
Published in Health and Medicine Week, September 19th, 2005
Scientists writing in the journal Thrombosis and Haemostasis report, "Several lines of evidence suggest that the chemokine fractalkine (FKN) and its receptor CX3CR1 contribute to the accumulation of leukocytes in the atherosclerotic plaque. The M280 allele of the CX3CR1T280M polymorphism modulates leukocyte recruitment and is associated with lower prevalence of cardiovascular disease. The influence of V249I, another CX3CR1 polymorphism, is discussed controversially."
A. Niessner and colleagues of the...
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