Colorectal Disease
Prophylactic colectomy recommended in patients with MYH-associated polyposis
Published in Health and Medicine Week, December 19th, 2005
According to recent research from Portugal, "The MYH gene has recently been associated with multiple colorectal tumors. It participates in the DNA base-excision-repair, avoiding mutations in other genes, namely the APC and Ki-ras."
"Recently, biallelic MY-H mutations have been described in patients with attenuated polyposis and in 7.5% with classic polyposis and no detectable A-PC mutation. The aim of this study was to analyze the incidence of germ-line MYH mutations in selected Portuguese families recorded in a hereditary tumor registry and to evaluate the risk of...
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