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Cancer Research

Double H10/Ki-67 immunostaining is useful to study breast cancer growth fraction

Published in Health and Medicine Week, December 26th, 2005

Double H10/Ki-67 immunostaining is a useful technique for studying growth fraction in breast carcinomas.

According to a study from Bulgaria, "Histone H10 is a linker histone subvariant present in tissues of low proliferation rate. It is supposed to participate in the expression and maintenance of the terminal differentiation phenotype."

N.N. Kostova and colleagues at the Institute of Molecular Biology in Sofia wrote, "We proposed to study histone H10 distribution in human breast carcinoma and its relationship with the processes of proliferation and differentiation. Most of the cells in carcinomas of moderate and high...

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