Obesity Pathogenesis
Pro-IGF-II is reduced in obese subjects
Published in Health and Medicine Week, February 20th, 2006
"In normal subjects up to 10% of circulating insulin-like growth factor II (IGF-II) consists of pro-IGF-II. However, its regulation and biological impact remains unknown. In obese subjects, serum free and total IGF-II are increased, and we, therefore, investigated the impact of obesity and diet on serum pro-IGF-II," researchers in Denmark report.
U. Espelund and colleagues working at Aarhus University Hospital explained, "Nondiabetic, obese subjects (n=34) with a body mass index (BMI) of 38.9±0.5 kg/m2 were subjected to 8 weeks with very low calorie diet (800 kcal/day) followed by 12 weeks...
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