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Coronary Heart Disease

Asian populations less likely to get relief from chest pain with nitroglycerin

Published in Health and Medicine Week, February 20th, 2006

Researchers have determined the reason some Asians with coronary heart disease don't respond to nitroglycerin treatment is a gene mutation.

Nitroglycerin, also called glyceryl trinitrate (GTN), has been widely used for the management of coronary heart disease, specifically angina and heart failure, for more than 130 years. The efficacy of GTN is determined by the ability of the body to convert it to nitric oxide (NO), a process that requires the enzyme mitochondrial aldehyde dehydrogenase-2 (ALDH2).

Li Jin and colleagues at Fudan University in China now show that the reason some Asians have trouble responding to GTN is that 30% to 50% of this...

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