Gastrointestinal Cancer
Pro1X enrolls first patient in phase 1B thioredoxin inhibitor trial for gastrointestinal cancer
Published in Health and Medicine Week, February 20th, 2006
This trial is designed to explore a new schedule of delivery with PX-12 given as a 24-hour infusion every 2 weeks, evaluating its safety, pharmacokinetic profile, and antitumor activity. The study will be conducted by Dr. Tomislav Dragovich at the Arizona Cancer Center in Tucson, Arizona.
PX-12 is a small molecule designed to inhibit thioredoxin, a protein which can stimulate cell growth and block apoptosis. The increased thioredoxin levels in...
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