Enzymology
Protein related to vaccinia virus methyltransferase is involved in Trypanosoma cap 4 modification
Published in Health and Medicine Week, February 27th, 2006
According to recent research published in the journal RNA, "The spliced-leader (SL) RNA plays a key role in the biogenesis of mRNA in trypanosomes by providing the m7G-capped SL sequence to the 5' end of every mRNA. The cap structure of the SL RNA is unique in eukaryotes with 4 nucleotides after the cap carrying a total of seven methyl groups and by convention is referred to as 'cap 4.' Although the enzymatic machinery for cap addition has been characterized in several organisms, including Trypanosoma...
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