Oncology
Breast cancer becomes more aggressive with TIMP3 gene hypermethylation
Published in Health and Medicine Week, March 13th, 2006
According to a study from the People's Republic of China, "Neoplastic cells often display aberrant methylation and silencing of multiple genes, including tumor suppressor genes (TSGs) that regulate critical processes such as cell cycle control, DNA repair and angiogenesis. TIMP3 is an extracellular matrix-bound protein which regulates matrix composition and affects tumor growth, invasion and angiogenesis."
"It mediates vascular endothelial growth factor (VEGF) by blocking the binding of VEGF to VEGF receptor-2 and inhibits downstream...
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