Diabetes Complications
Impaired angiogenesis factors are not linked to vessel dysfunction in diabetic foot
Published in Health and Medicine Week, March 13th, 2006
According to recent research published in the journal Circulation Research, "Diabetic foot is caused by microangiopathy and is suggested to be a result of impaired angiogenesis. Using a severe hindlimb ischemia model of streptozotocin-induced diabetic mice (STZ-DM), we show that diabetic foot is a disease solely of the disturbance of platelet-derived growth factor B-chain homodimer (PDGF-BB) expression but not responses of angiogenic factors."
"STZ-DM mice frequently lost their hindlimbs after induced ischemia, whereas non-DM mice did not. Screening of...
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