Published in Health and Medicine Week, March 13th, 2006
According to recent research published in the journal Circulation Research, "Diabetic foot is caused by microangiopathy and is suggested to be a result of impaired angiogenesis. Using a severe hindlimb ischemia model of streptozotocin-induced diabetic mice (STZ-DM), we show that diabetic foot is a disease solely of the disturbance of platelet-derived growth factor B-chain homodimer (PDGF-BB) expression but not responses of angiogenic factors."
"STZ-DM mice frequently lost their hindlimbs after induced ischemia, whereas non-DM mice did not. Screening of...
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