Published in Health and Medicine Week, March 13th, 2006
"A major limitation in cancer gene therapy, specifically gene-dependent enzyme prodrug therapy (GDEPT), is inefficient gene delivery and expression. The suicide gene CD and its substrate, 5-fluorocytosine (5-FC), have been extensively explored due to the inherent bystander effect achieved through diffusion of the toxic metabolite 5-fluorouracil (5-FU)."
"In this study," wrote K.C. Lee and colleagues, University of Michigan, "we aimed...
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