Acid Reflux
Rabeprazole may be a valuable step-down therapy for gastroesophageal reflux disease
Published in Health and Medicine Week, April 13th, 2006
According to recent research from Japan, "To improve clinical outcomes of the initial therapy for gastroesophageal reflux disease, intragastric pH should be above 4.0 for more than 20 hours a day (83.3%) and nocturnal gastric acid breakthrough, defined as 60 continuous minutes of intragastric pH below 4.0 at night, should be inhibited."
T. Shimatani and colleagues from Hiroshima University Hospital wrote, "A 'step-down' therapy sometimes fails because of insufficient acid suppression. Therefore we compared the acid-suppressive effects of proton pump inhibitors. This was...
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