Leukemia
FLT3 D324N variant may be associated with a predisposition to different leukemia subtypes
Published in Health and Medicine Week, April 27th, 2006
"Mutations within the FLT3 gene are of growing importance for classification, risk assessment, and therapeutic targeting of acute myeloid leukemia (AML). We analyzed 656 AML patients for a recently described single-nucleotide polymorphism in the third immunoglobulin-like domain of the extracellular region of FLT3," wrote S. Schnittger and colleagues, University Hospital Grosshadern.
"The FLT3 D324N variant was present in 42 cases (6.4%), but it was not associated with a specific AML subtype and did not show an elevated...
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