Pancreatic Cancer
Pancreatic cancer cell invasion declines upon Notch-1 inhibition
Published in Health and Medicine Week, April 27th, 2006
According to recent research from the United States, "Notch signaling plays a critical role in the pathogenesis and progression of human malignancies but the precise role and mechanism of Notch-1 for tumor invasion remains unclear. In our earlier report, we showed that down-regulation of Notch-1 reduced nuclear factor-kappa B (NF-kappa B) DNA-binding activity and matrix metalloproteinase-9 (MMP-9) expression."
"Because NF-kappa B, vascular endothelial growth factor (VEGF), and MMPs are critically involved in the processes of tumor cell invasion and metastasis, we investigated the role...
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