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Squamous Cell Carcinoma

Cutaneous squamous cell carcinoma tumorigenesis requires Stat3 activation

Published in Health and Medicine Week, April 27th, 2006

According to recent research from Japan published in the journal Experimental Dermatology, cutaneous squamous cell carcinoma proliferation and tumorigenesis requires signal transducer and activator of transcription 3 (Stat3) activation.

"Stat3, a cytoplasmic transcription factor, is constitutively activated in various types of cancer. Previous investigations have demonstrated that Stat3 plays important roles in cell growth, survival, differentiation, and transformation," wrote N. Sumita and colleagues, Kobe University Graduate School of Medicine.

They continued, "The constitutive activation of Stat3 in human malignancies is an important key to...

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