Tularemia Vaccine
Francisella tularensis grey variants do not induce immunity
Published in Health and Medicine Week, April 27th, 2006
According to a study from England, "Francisella tularensis live vaccine strain (LVS) produces two colony types when grown on solid media, often referred to as blue variants (BV) and grey variants (GV). Whereas blue variant bacteria possessed a lipopolysaccharide O-side chain, grey variant bacteria lacked O-side chains."
"Grey variant bacteria appeared in stationary phase bacterial cultures and could be identified using a novel FACS-based...
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