DNA Vaccine
CTLA-4-mediated targeting and CpG motifs enhance immunogenicity of DNA vaccines
Published in Health and Medicine Week, April 27th, 2006
"DNA vaccines have proven to be an efficient means of inducing immune responses in small laboratory animals; however, their efficacy in large out-bred animal models has been much less promising," note scientists in Australia and Canada. "In addressing this issue, we have investigated the ability of ovine cytotoxic lymphocyte antigen 4 (CTLA-4) mediated targeting and ruminant specific CpG optimized plasmids, both alone and in combination, to enhance immune responses in sheep to the pro cathepsin B (FhCatB) antigen from Fasciola hepatica."
"In...
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