Stem Cell Transplantation
Mixed chimerism induced via CD45-congenic mobilized PBSCT post-nonmyeloablative irradiation
Published in Health and Medicine Week, May 18th, 2006
According to a study from Austria, "Clinical translation of the mixed-chimerism approach for inducing transplantation tolerance would be facilitated if mobilized peripheral blood stem cells (mPBSCs) could be used instead of bone marrow cells (BMCs).
"Because the use of mPBSCs for this purpose has not been investigated in nonmyeloablative murine protocols, we explored the engraftment potential of mPBSCs in a CD45-congenic model as a first step."
"After 2, 1.5, or 1 Gy of total body irradiation,...
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