Cancer Therapy

Dimeric cinnamaldehydes synthesized as potent antitumor agents

Published in Health and Medicine Week, May 18th, 2006

A study from South Korea has documented the synthesis of dimeric cinnamaldehydes as potent antitumor agents.

"It has been reported that 2-hydroxycinnamaldehyde and 2-benzoyl-oxycinnamaldehyde inhibited the activity of farnesyl protein transferase, angiogenesis, cell-cell adhesion, and tumor growth in vivo model. In order to improve its anti-tumor activity., dimeric cinnamaldehydes have been synthesized based oil 2-hydroxycinnamaldehyde," wrote D.S. Shin and colleagues, Korea Research Institute of Bioscience & Biotechnology.

"The synthesized compounds strongly inhibited the growth of human colon tumor cells with GI₅₀ values of 0.6-10 mcM....

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Source: Health and Medicine Week (2006-05-18)

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