Published in Health and Medicine Week, May 18th, 2006
"DNA damage induced by the topoisomerase I inhibitor irinotecan (CPT-11) triggers in p53(WT) colorectal carcinoma cells a long term cell cycle arrest and in p53(MUT) cells a transient arrest followed by apoptosis (Magrini, R., et al. (2002) Int. J. Cancer 101, 23-31; Bhonde, M.R., et al. (2006) Oncogene 25, 165-175). The mechanism of the p53-independent apoptosis still remains largely unclear," wrote M.R. Bhonde and colleagues, Charite-Universitatsmedizin.
They explained, "Here we used five p53(WT) and five p53(MUT) established colon carcinoma cell...
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