Hepatitis C Virus
HCV NS5B-nucleolin interaction with subgenomic replicon permits replication
Published in Health and Medicine Week, May 18th, 2006
"We previously reported that nucleolin, a representative nucleolar marker, interacts with NS5B of HCV through two independent regions of NS5B, amino acids 208 to 214 and 500 to 506. We also showed that truncated nucleolin that harbors the NS5B-binding region inhibited the RNA-dependent RNA polymerase activity of NS5B in vitro, suggesting that nucleolin may be involved in HCV replication," wrote T. Shimakami and colleagues, Kanazawa University. "To address this question, we focused on NS5B amino acids 208 to...
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